The present invention is directed to certain fused pyrimidines having a homo or hetero cyclopentyl, cyclohexyl or cycloheptyl ring as the pyrimidine fusion partner； having an amino benzyl or substituted amino benzyl group at the 4 position of the pyrimidine ring； and a 5:6 heterobicyclo ring with at least one N, O or S at the 2 position of the pyrimidine ring. These compounds are useful for treatment of cancer by inhibition of the p97 complex.本發明係關於某些稠合嘧啶，其具有同環或雜環環戊基、環己基或環庚基環作為嘧啶稠合配偶體；在該嘧啶環之4位處具有胺基苄基或經取代胺基苄基；且在該嘧啶環之2位處具有擁有至少一個N、O或S之5：6雜雙環。該等化合物可用於藉由抑制p97錯合物來治療癌症。
