GEKKIEVA, MARGARITA,WARBURTON, JAMES,SALLSTIG, PETER,SCHMIDT, WERNER,WEICHSELBERGER, ANDREAS
申请号：
SG11201702954X
公开号：
SG11201702954XA
申请日:
2015.11.06
申请国别(地区):
SG
年份:
2017
代理人:
摘要：
The present invention provides anti-VEGF antibodies formulated as high concentration, aqueous pharmaceutical compositions, suitable for an injection, preferably an intravitreal injection. The aqueous pharmaceutical compositions are useful for delivery of a high concentration of the antibody active ingredient to a patient without high levels of antibody aggregation and without a high level of sub-visible particulate matter. An aqueous composition of the invention comprises an antibody having a concentration of at least 50 mg/ml. An aqueous pharmaceutical composition of the invention includes a sugar, a buffering agent, and a surfactant.
