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ИММУНОГЕННЫЕ КОМПОЗИЦИИ АНТИГЕНОВ Staphylococcus aureus
专利权人:
Вайет ЭлЭлСи (US)
发明人:
АНДЕРСОН Анналиеса (US),ПАВЛЬЯК Вильям (US),ЯНСЕН Катрин Уте (US),ДОДЖ Ингрид Лиа (US),БЭЙКЕР Стивен Моррис (US),НАНРА Джасдил Сингх (US),МЕРФИ Эллен (US),ГРИН Брюс Артур (US),РАППЕН Марк Эдвард (US)
申请号:
RU2011151781/10
公开号:
RU2011151781A
申请日:
2010.06.22
申请国别(地区):
RU
年份:
2013
代理人:
摘要:
1. An immunogenic composition comprising at least three components selected from the group consisting of an isolated polypeptide clumping factor A S.aureus (ClfA), isolated polypeptide clumping factor B S.aureus (ClfB), the isolated protein MntC S.aureus, isolated capsular polysaccharide type 5 S.aureus, conjugated to a carrier protein and the capsular polysaccharide selected type 8 S.aureus, protein-conjugated nositelem.2. An immunogenic composition comprising the isolated polypeptide clumping factor A S.aureus (ClfA), a dedicated type 5 capsular polysaccharide S.aureus, conjugated to a carrier protein and the capsular polysaccharide selected type 8 S.aureus, conjugated to a protein nositelem.3. The immunogenic composition of claim 2, further comprising isolated protein MntC S.aureus.4. An immunogenic composition comprising isolated protein MntC S.aureus, isolated capsular polysaccharide type 5 S.aureus, conjugated to a carrier protein and the capsular polysaccharide selected type 8 S.aureus, conjugated to a protein nositelem.5. An immunogenic composition according to any one of claims 2 or 4, further comprising an isolated polypeptide clumping factor B S.aureus (ClfB) .6. An immunogenic composition according to any one of claims 1, 2 or 4, wherein ClfA polypeptide is a polypeptide fragment selected from the group consisting of fibrinogensvyazyvayuschego domain domains N1, N2 and N3 and domains N2 and N3 ClfA.7. An immunogenic composition according to any one of claims 1, 2 or 4, wherein ClfB polypeptide is a polypeptide fragment selected from the group consisting of fibrinogensvyazyvayuschego domain domains N1, N2 and N3 and domains N2 and N3 ClfB.8. An immunogenic composition according to any one of claims 1, 2 or 4, wherein the polypeptide binds to the ClfA fibrinogen IU1. Иммуногенная композиция, содержащая по меньшей мере три компонента, выбранных из группы, состоящей из выделенного полипептида фактора слипания A S.aureus (ClfA), выделенного полипептида фактор
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