The present invention includes methods for identifying modifiers of chemosensory receptors and their ligands, e.g., by determining whether a test entity is suitable to interact with one or more interacting sites within the Venus flytrap domains of the chemosensory receptors, and modifiers capable of modulating chemosensory receptors and their ligands. The present invention also includes modifiers of chemosensory receptors and their ligands having Formula (I), its subgenus, and specific compounds. Furthermore, the present invention includes ingestible compositions comprising the modifiers of chemosensory receptors and their ligands and methods of using the modifiers of chemosensory receptors and their ligands to enhance the sweet taste of an ingestible composition or treat a condition associated with a chemosensory receptor. In addition, the present invention include processes for preparing the modifiers of chemosensory receptors and their ligands.本發明包括確認化學感官受體及其配位體之改質劑之方法，例如藉由測定待測實體是否適合與化學感官受體之Venus flytrap功能部位內之一或多個交互作用位置交互作用，及能夠調節化學感官受體及其配位體之改質劑。本發明亦包括具有式(I)之化學感官受體及其配位體之改質劑，其亞屬，及特定化合物。再者，本發明包括可攝食組合物，其包含化學感官受體及其配位體之改質劑，及使用化學感官受體及其配位體之改質劑以增強可攝食組合物之甜味，或治療與化學感官受體有關聯症狀之方法。此外，本發明包括製備化學感官受體及其配位體之改質劑之方法。
