This method outlines a process which a patient may follow to find a rapid, safe and effective treatment for the common problem of premature ejaculation. The method progresses through three stages including clinical history, diagnostic testing, and treatment. Treatment of primary premature ejaculation includes assessing the condition of the male to establish that the male has primary premature ejaculation as opposed to secondary premature ejaculation and, if the male is diagnosed as having primary premature ejaculation, identifying a treatment protocol that progresses to a safest and most effective methodology in a shortest number of steps. During treatment, the male is progressed through at least two of the following steps in sequence until a satisfactory delay of ejaculation is achieved: applying a clomipramine sublingual spray, applying a clomipramine nasal spray, applying a troche of clomipramine buccally or sublingually, applying tramadol buccally, and injecting a vasodilator into a corpus cavernosum of the male's penis in an amount sufficient to provoke a lasting erection.
