ПАНОУСИС Кон (AU),РАЙЗМАН Вероника (AU),НАШ Эндрю (AU),УИЛСОН Майкл (AU),ШМИДБАУЭР Штефан (DE),НОЛЬТЕ Марк (DE)
申请号：
RU2014106652/15
公开号：
RU2014106652A
申请日:
2012.07.20
申请国别(地区):
RU
年份:
2015
代理人:
摘要：
1. A monoclonal antibody against factor XII / XIIa or its antigennegative fragment, the binding affinity of human factor XIIa-beta which is 2 times greater than the binding affinity of human factor XII, and which is able to completely inhibit the amidolytic activity of human factor XIIa. 2. A monoclonal antibody against factor XII / XIIa or an antigen binding fragment thereof which inhibits factor XIIa-alpha is 50% greater when used in a molar ratio of FXIIa-alpha to antibody of 1: 0.2.3. An antibody or antigen binding fragment thereof according to claim 1 or 2, wherein the antibody binds mouse FXII / FXIIa； and in which the level of binding of the antibody to the polypeptide containing the sequence of SEQ ID NO: 2, in which (a) the asparagine residue at position 398 of the sequence SEQ ID NO: 2 is replaced by lysine； or (b) the isoleucine residue at position 438 of the sequence SEQ ID NO: 2 is replaced by alanine, lower than the level of protein binding to the corresponding polypeptide containing the sequence SEQ ID NO: 2 without the indicated substitution. 4. An antibody or antigen binding fragment thereof according to claim 1 or 2, wherein the antibody contains a heavy chain variable region (vH) that is more than 85% identical to the sequence of SEQ ID NO: 4.5. The antibody or fragment thereof according to claim 1 or 2, wherein the antibody comprises a light chain variable region (vL) that is more than 85% identical to the sequence of SEQ ID NO: 5.6. The antibody or fragment thereof according to claim 1 or 2, wherein the antibody contains a heavy chain CDR1 that is at least 80% identical to SEQ ID NO: 6, a heavy chain CDR2 that is at least 60% identical to SEQ ID NO : 7, and CDR3 of the heavy chain, which is at least 80% identical in1. Моноклональное антитело против фактора XII/XIIa или его антигенсвязывающий фрагмент, аффинность связывания с фактором XIIa-бета человека которого в 2 раза больше аффинности связывания с фактором XII человека, и которое способно пол
