Christophe Arbogast;Hong Fan;Aaron K. Sato;Edmund R. Marinelli;Daniel T. Dransfield;Philippe Bussat;Robert C. Ladner;Karen E. Linder;Palaniappa Nanjappan;Adrian D. Nunn;Sudha Khurana;Daniel J. Sexton
发明人:
Aaron K. Sato,Daniel J. Sexton,Daniel T. Dransfield,Robert C. Ladner,Christophe Arbogast,Philippe Bussat,Hong Fan,Sudha Khurana,Karen E. Linder,Edmund R. Marinelli,Palaniappa Nanjappan,Adrian D. Nunn
申请号：
US12480578
公开号：
US08642010B2
申请日:
2009.06.08
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present invention provides polypeptides, peptide dimer, and multimeric complexes comprising at least one binding moiety for KDR or VEGF/KDR complex, which have a variety of uses wherever treating, detecting, isolating or localizing angiogenesis is advantageous. Particularly disclosed are synthetic, isolated polypeptides capable of binding KDR or VEGF/KDR complex with high affinity (e.g., having a KD<；1 μM), and dimer and multimeric constructs comprising these polypeptides.
