作爲突變ＩＤＨ抑制劑之３－嘧啶－４－基－唑啶－２

发明人:: CAFERRO, THOMAS RAYMOND,加菲洛　汤玛士　雷蒙德,加菲洛　湯瑪士　雷蒙德,CHEN, ZHUOLIANG,陈卓亮,陳卓亮,CHO, YOUNG SHIN,赵英伸,趙英伸,COSTALES, ABRAN Q.,扣斯泰尔斯　阿比瑞恩Ｑ,扣斯泰爾斯　阿比瑞恩Ｑ,LEVELL, JULIAN ROY,拉维尔　茱莉安　罗伊,拉維爾　茱莉安　羅伊,LIU, GANG,刘纲,劉綱,MANN,加菲洛汤玛士雷蒙德,加菲洛湯瑪士雷蒙德,扣斯泰尔斯阿比瑞恩Q,扣斯泰爾斯阿比瑞恩Q,拉维尔茱莉安罗伊,拉維爾茱莉安羅伊

摘要：: The invention is directed to a formula (I): or a pharmamceutically acceptable salt thereof, wherein R1, R2a, R2b and R3-R7 are herein. The invention is also directed to compositions containing a compound of formula (I) and to the use of such compounds in the inhibition of mutant IDH proteins having a neomorphic activity. The invention is further directed to the use of a compound of formual (I) in the treatment of diseases or disorders associated with such mutant IDH proteins including, but not limited to, cell-proliferation disorders, such as cancer.本發明係關於式(I)：或其醫藥學上可接受之鹽，其中R1、R2a、R2b及R3-R7係在本文中定義。本發明亦關於含有式(I)化合物之組合物及該等化合物用於抑制具有新生形活性之突變IDH蛋白質的用途。本發明進一步關於式(I)化合物用於治療與該等突變IDH蛋白質有關之疾病或病症之用途，該等疾病或病症包括(但不限於)細胞增殖病症，諸如癌症。