An adsorbing material for multiple pathogenic factors of sepsis as well as a preparation method and an application thereof. The adsorbing material is formed by coupling a carrier with good mechanical performance and blood compatibility and a ligand with the capacity to adsorb multiple pathogen associated molecules, is capable of effectively adsorbing bacterial endotoxin, bacterial genome DNA, peptidoglycan, teichoic acid, virus RNA, and zymosan from fluids such as blood and the like, and in particular has application value in blood purification treatment of sepsis.
