CARROLL, WILLIAM A.,DART, MICHAEL J.,FROST, JENNIFER M.,KOLASA, TEODOZYJ,LI, TONGMEI,LIU, BO,PEREZ-MEDRANO, ARTURO,PATEL, MEENA,WANG, XUEQING,PEDDI, SRIDHAR
申请号：
ES12187944
公开号：
ES2545655T3
申请日:
2009.09.08
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
A compound according to formula (I), ** Formula ** or a pharmaceutically acceptable salt or solvate thereof, where X1 is O or N (Rbx)； wherein Rbx is hydrogen, alkyl, haloalkyl, alkoxyalkyl, -C (O) O (alkyl), monocyclic cycloalkyl, - (CR1cR1d) q3- (monocyclic cycloalkyl), or haloalkoxyalkyl； and A1 is -N (Rb) C (O) Ra, -N (Rb) C (O) ORd, -N (Rb) C (O) N (Rb) (Rc), -N (Rb) (Rc) , or -N>； = C (Rp) (Rq)； or X1 and A1 together are N>； = N (Rcx)； wherein Rcx is alkyl, haloalkyl, - (CR1aR1b) q3-A3, G1d, or - (CR1aR1b) q3-G1d； Rp is hydrogen, alkyl, haloalkyl, - (CR1aR1b) q3-A3, -C (O) ORd, -C (O) Rd, G1d, O- (CR1aR1b) q3-G1d； Rq is hydrogen, alkyl, haloalkyl, -N (Rb) (Rc), - (CR1aR1b) q3-A3, G1d, or - (CR1aR1b) q3-G1d； or Rp and Rq, together with the carbon atom to which they are attached, form a 5, 6, 7, or 8-membered cycloalkyl or heterocyclic ring, optionally substituted with 1, 2, 3, 4, or 5 independently selected substituents from the group consisting of oxo, alkyl, haloalkyl, and halogen； A3 is C (O) Rh, -S (O) 2Re, -C (O) N (Rh) 2, -C (S) N (Rh) 2, -S (O) 2N (Rh) 2, -C (>； = NORh) Rh, -N (Rh) C (O) Rh, -N (Rh) C (O) ORe, -N (Rh) S (O) 2Re, -N (Rh) C (O) N (Rh) 2, -N (Rh) S (O) 2N (Rh) 2, - CN, -ORj, or -N (Rh) 2； Ra and Rc, at each occurrence, are each independently hydrogen, alkyl, haloalkyl, - (CR1aR1b) q3-O-alkyl, - (CR1aR1b) q3-A3, G1d, or - (CR1aR1b) q3-G1d； Rb, at each occurrence, is each independently hydrogen, alkyl, haloalkyl, alkoxyalkyl, cycloalkyl, - (CR1cR1d) q3- (cycloalkyl), or haloalkoxyalkyl； Rd, at each occurrence, is alkyl, haloalkyl, - (CR1aR1b) q3-O-alkyl, - (CR1aR1b) q3-A3, G1a, or - (CR1aR1b) q3-G1d； RJ is hydrogen, C1-C4 haloalkyl, monocyclic cycloalkyl, or - (CR1cR1d) q3- (monocyclic cycloalkyl)； R1b, at each occurrence, is independently hydrogen, halo, C1-C4 alkyl, C1-C4 haloalkyl, -ORh, -N (Rh) 2, -N (Rh) C (O) Rh, -N (Rh) C ( O) ORe, or -N (Rh) S (O) 2Re； G1d, at each occurrence, is independently a monocyclic heterocycle, a monocyc
