The present invention relates to 5-substituted isoindoline compounds of formula (III)or formula (IV)wherein R10, R11, R13, R14, X and Y are as defined herein； or a pharmaceutically acceptable salt, solvate, stereoisomer, or prodrug thereof. The present invention also relates to a pharmaceutical composition of the compounds of the invention. The present invention also relates to a compound of the invention for use in treating, managing or preventing disease conditions as disclosed herein.
