A spinal implant system comprises a plurality of alternate first members including at least one first member. The first member comprises an inner surface defining an implant cavity, and a first part being non-rotatable relative to the inner surface and a second part movable relative to the first part. A second member includes a mating element engageable with a first member such that the second member is interchangeable with the plurality of first members. The first member is rotatable relative to the second member in a first plane of a body and the second part defines a portion of the implant cavity and is movable relative to the first part in a second plane of the body. Fasteners, instruments and methods are disclosed.