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مركبات امفيتامينية مقاومة اساءه الاستخدام
专利权人:
SHIRE LLC
发明人:
MICKLE TRAVIS,KRISHNAN SUMA,BISHOP BARNEY,LAUDERBACK CHRISTOPHER,MONCRIEF JAMES SCOTT,OBERLENDER ROB,بيرنارد جى. بول,كريستوفر ايه. فيربيكى
申请号:
EGNA2005000769
公开号:
EG26032A
申请日:
2005.11.27
申请国别(地区):
EG
年份:
2012
代理人:
摘要:
The invention describes compounds, compositions, and methods of using the same comprising a chemical moiety covalently attached to amphetamine. These compounds and compositions are useful for reducing or preventing abuse and overdose of amphetamine. These compounds and compositions find particular use in providing an abuse-resistant alternative treatment for certain disorders, such as attention deficit hyperactivity disorder (ADHD), ADD, narcolepsy, and obesity. Oral bioavailability of amphetamine is maintained at therapeutically useful doses. At higher doses bioavailability is substantially reduced, thereby providing a method of reducing oral abuse liability. Further, compounds and compositions of the invention decrease the bioavailability of amphetamine by parenteral routes, such as intravenous or intranasal administration, further limiting their abuse liability.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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