Singh, Manmohan,Skibinski, David A.G.,Wu, Tom, Yao-hsiang,Li, Yongkai,Cortez, Alex,Zhang, Xiaoyue,Zou, Yefen,Hoffman, Timothy,Pan, Jlanfeng,Yue, Kathy
申请号：
AU2016204450
公开号：
AU2016204450A1
申请日:
2016.06.28
申请国别(地区):
AU
年份:
2016
代理人:
摘要：
#$%^&*AU2016204450A120160728.pdf#####ADSORPTION OF IMMUNOPOTENTIATORS TO INSOLUBLE METAL SALTS ABSTRACT OF THE DISCLOSURE Immunopotentiators can be adsorbed to insoluble metal salts, such as aluminium salts, to modify their pharmacokinetics, pharmacodynamics, intramuscular retention time, and/or immunostimulatory 5 effect. Immunopotentiators are modified to introduce a moiety, such as a phosphonate group, which can mediate adsorption. These modified compounds can retain or improve their in vivo immunological activity even when delivered in an adsorbed form.
