BARF, TJEERD A.,JANS, CHRISTIAAN GERARDUS JOHANNES MARIA,MAN, DE ADRIANUS PETRUS ANTONIUS,OUBRIE, ARTHUR A.,RAAIJMAKERS, HANS C.A.,REWINKEL, JOHANNES BERNARDUS MARIA,STERRENBURG, JAN-GERARD,WIJKMANS,
申请号：
PE2014000096
公开号：
PE20141681A1
申请日:
2012.07.11
申请国别(地区):
PE
年份:
2014
代理人:
摘要：
It refers to a compound of formula I, where x is ch, N, O, s, it is n, O,S； Z is ch, n or key； a is ch or N； B1, B2, B3, B4 is n or C (R7),C (R8),C (R9),C (R10) respectively； R1 is r11c (o),That's it.R13so2； R2 is h, asphalt (1c-3c),1. Cyclopropyl (3c-7c)；R3 is h, 1-6C,1. Cyclopropyl (3c-7c)；R4 is h, or tenant (1c-3c)；R5 is h, halogen, cyanogen, etc.； R6 is h or tar (1c-3c)；R7 is h, halogen or Alcoy； R8 is h or tar (1c-3c)；R9 and R10 are independent h, halogen or oxygen (1c-3c)；R11 is a lease (1c-6c),2. Alquenilo (2c-6c) and hydrocarbyl (2c-6c),Among other things, R12 and R13 are independent alquenio (2c-6c),1. Asphalt (2c-6c)；R14 is halogen, cyanogen and acyl (2c-6c),There are others The most popular compounds are: (s) - 4 - (3 - (1-acrylonitrile-pyridinediol-2-il) - 8-aminodihydrazide [1,5-a] pyridine-1-il) - benzodiazepine (pyridine-2-il)； (s, e) - 4 - (8-amine-3 - (1 - (4 - (pirrolidin-1-il) but-2-enoil) Pyridine-2 - (1,5-a) pyridine-1 - (1) - pyr-pyr-pyr-pyr-pyr-pyr-pyr. This compound is a Btk inhibitor (kinasa, Burton's thyroid hormone), also known as a pharmacological synthesis, and is useful in the treatment of non Hodgkin lymphoma and leukemia.SE REFIERE A UN COMPUESTO DE FORMULA I, DONDE: X ES CH, N, O, S； Y ES N, O , S； Z ES CH, N O ENLACE； A ES CH O N； B1, B2, B3, B4 SON N O C(R7), C(R8), C(R9), C(R10) RESPECTIVAMENTE； R1 ES R11C(O), R12S(O), R13SO2； R2 ES H, ALQUILO (1C-3C), CICLOALQUILO (3C-7C)； R3 ES H, ALQUILO (1C-6C), CICLOALQUILO (3C-7C)； R4 ES H O ALQUILO (1C-3C)； R5 ES H, HALOGENO, CIANO, ENTRE OTROS； R6 ES H O ALQUILO (1C-3C)； R7 ES H, HALOGENO O ALCOXI； R8 ES H O ALQUILO (1C-3C)； R9 Y R10 SON INDEPENDIENTEMENTE H, HALOGENO O ALCOXI (1C-3C)； R11 ES ALQUILO (1C-6C), ALQUENILO (2C-6C) Y ALQUINILO (2C-6C), ENTRE OTROS； R12 Y R13 SON INDEPENDIENTEMENTE ALQUENILO (2C-6C), ALQUINILO (2C-6C)； R14 ES HALOGENO, CIANO, ALQUENILO (2C-6C), ENTRE OTROS. SON COMPUESTOS PREFERIDOS: (S)-4-(3-(1-ACRILOILPIRROLIDIN-2-IL)-8-AMINOIMIDAZOL[1,5-A]PIRAZIN-1-IL)-N-(PIR
