The present invention aims to provide a porous hollow fiber membrane for the treatment of a protein-containing liquid, which can effectively separate and remove a substance to be removed such as small diameter virus contained in the liquid, and which can allow effective permeation of a useful substance to be recovered such as protein in high concentration. The porous hollow fiber membrane of the present invention is characterized in that the hollow fiber membrane consists of an asymmetric structure having a dense layer in an outer layer only and contains a hydrophobic polymer and a first hydrophilic polymer, that the surface and the porous part of said hollow fiber membrane are coated with a second hydrophilic polymer, that said hydrophobic polymer is a polysulfone-type polymer, that said first hydrophilic polymer is a copolymer of vinylpyrrolidone with vinyl acetate, and that said second hydrophilic polymer is a polysaccharide or a polysaccharide derivative. The porous hollow fiber membrane of the present invention is obtained by a method comprising a step wherein a porous hollow fiber membrane is formed using a dope prepared by co-dissolving the hydrophobic polymer and the first hydrophilic polymer in the same solvent and then the second hydrophilic polymer is coated on the surface and the porous part of the hollow fiber membrane.
