Device (1) for transcutaneous biopsy comprising a shell (2) consisting of a first half (P) of shell and a second half (Q) of shell that can be fixed together, being defined within said housing (2) a chamber (3) inside which a sliding element (E) can slide in a sliding direction, a first cannula (A) being connected to said sliding element (E), consisting of a first hollow cylindrical body, and a second cannula (C), which consists of a second hollow cylindrical body, said first cannula (A) and said second cannula (C) having a common longitudinal axis (Z) parallel with respect to said sliding direction, said second cannula being inserted (C ) in said first cannula (A), said first cannula (A) being provided at its distal end with a blocking element (B) suitable for interacting with said second cannula (C), said blocking element (B) comprising a third cylindrical body h a socket fixed inside said distal end of the first cannula (A), said third hollow cylindrical body being provided at a proximal end of a pair of notches (B10), said second cannula (C) being provided at its distal end of a pair of sheet elements (C10) that are diametrically opposed to each other and that are suitable for interacting with said pair of notches (B10), characterized by the fact that said notches (B10) end at their distal end against a wall of said third cylindrical body in an area where said wall has a pair of diametrically opposed bevels (B20) designed to interact with said sheet elements (C10) to deflect the sheet elements (C10) towards a longitudinal axis (Z) which is common to said second cannula (C) and said first cannula (A), and by the fact that a proximal end of said first cannula (A) is fixed to a first actuating element (H) suitable for rotating said first cannula ( A) around said longitudinal axis (Z), said first drive element (H) being connected by means of a connection element (J) to a second drive element (I) fixed in rotation to said second cannula (C), comprising said second dr
