Shubiao ZHANG,Huiying CHEN,Yu MA,Xiaoli QIN,Haoming LAN,Shaohui CUI
申请号：
US16466362
公开号：
US20190338051A1
申请日:
2017.12.04
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The present invention provides a preparation method of a redox-responsive chitosan-liposome and use thereof, wherein the method uses dithiobis succinimidyl-substituted ester to synthesize a redox-responsive and disulphide bonded double fatty chain substituent phosphatidylethanolamine-s-s-chitosan. Using the synthesized double fatty chain substituent phosphatidylethanolamine chitosan, by a post-insertion and self-assembly method, to modify liposome, to construct a double fatty chain substituent phosphatidylethanolamine chitosan-liposome drug carrier having a redox-responsive chitosan brush on the surface thereof. The chitosan-liposome constructed in the present invention not only has the strong cell adhesion property and the antiserum property, but also has environmental response properties, being suitable for the intravenous injection. The present invention also provides the use of the chitosan-liposome encapsulating super-paramagnetic ferroferric oxide nanoparticles in drug delivery, which has high drug delivery efficiency and high biocompatibility, and has broad application prospects.
