DELUCA, HECTOR F.,TADI, BULLI PADMAJA,PLUM, LORI A.,CLAGETT-DAME, MARGARET
申请号：
CA2588401
公开号：
CA2588401C
申请日:
2005.11.18
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
This invention discloses 17(20)-dehydro-vitamin D analogs, and specifically17(Z)-1.alpha.,25-dihydroxy-17(20)-dehydro-2-methylene-19-nor-vitamin D3 andpharmaceutical usestherefor. This compound has use as an anti-cancer agent, in the treatment ofskin diseases andskin conditions and in the treatment of autoimmune disorders and inflammatorydiseases aswell as renal osteodystrophy and obesity. The compounds have the formula I:(see formula I)where Y1 and Y2 are each hydrogen or a hydroxy protecting group, where R11 andR12 areeach hydrogen, where R6 and R7 are hydrogen, alkyl, hydroxyalkyl, fluoroalkyl,hydroxy oralkoxy, or R6 and R7 when taken together may represent the group -(CH2)x-where x is aninteger from 2 to 5, or R6 and R7 when taken together may represent the group=CR8R9 whereR8 and R9 are hydrogen, alkyl, hydroxyalkyl, fluoroalkyl, hydroxy or alkoxy,or when takentogether R8 and R9 may represent the group -(CH2)x- where x is an integer from2 to 5, andwhere the group R represents typical side chains known for vitamin D typecompounds.
