The Government of the United States of America; as represented by the Secretary; Department of Health & Human Services
发明人:
Kinney, Richard M.,Kinney, Claire Y. H.,Butrapet, Siritorn,Gubler, Duane L.,Bhamarapravati, Natth
申请号：
ES10177474
公开号：
ES2554254T3
申请日:
2001.02.16
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
Composition Immunogenic flavivirus, comprising (i) a chimera nucleic acid comprising a first nucleotide sequence encoding nonstructural proteins and a capsid protein (C) of a dengue virus 2, in which the C protein does not include the signal peptide C-terminal of the C protein of dengue 2 and a second nucleotide sequence encoding the signal peptide C-terminal of the C protein, a premembrane (prM) and envelope protein (E) West Nile virus, or (Ii) a first nucleic acid comprising a nucleotide sequence encoding a strain of dengue-2 PDK53 attenuated virus a second nucleic acid comprising a nucleotide sequence encoding nonstructural proteins and a capsid protein (C) a PDK53 strain of dengue-2 attenuated virus and a nucleotide sequence encoding the proteins of premembrane (prM) and cover (E) of dengue 1 virus or comprising a nucleotide sequence encoding nonstructural proteins from a PDK53 strain of dengue-2 attenuated virus and a nucleotide sequence encoding proteins C, prM and E of dengue virus 1 a third nucleic acid comprising a nucleotide sequence encoding nonstructural proteins and a protein C a PDK53 strain of dengue-2 attenuated virus and a nucleotide sequence encoding the prM and E proteins of dengue-3 virus, wherein the E protein contains a leucine at amino acid position 345 and a fourth nucleic acid comprising a nucleotide sequence encoding nonstructural proteins and a protein C a PDK53 strain of dengue-2 attenuated virus and a nucleotide sequence encoding the prM and E proteins of dengue-4 virus, in the E protein contains a leucine at amino acid position 447 and wherein the protein C contains a serine at position 100 wherein the immunogenic composition comprises a pharmaceutically acceptable carrier or vehicle or adjuvant.Composición de flavivirus inmunógena, que comprende (i) una quimera de ácido nucleico que comprende una primera secuencia de nucleótidos que codifica proteínas no estructurales y una proteína de cápside (C) de un virus del dengue 2, en la que l
