Tert-butyl n-[2-{ 4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2h)-yl]-3,5-difluorophenyl} ethyl]-l-alaninate or a salt, hydrate or solvate thereof
Pintat Stéphane,Davies Stephen John,Moffat David Festus Charles
申请号：
NZ70671713
公开号：
NZ706717A
申请日:
2013.10.15
申请国别(地区):
NZ
年份:
2018
代理人:
摘要：
The present invention provides a compound which is: tert-butyl N-[2-{ 4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]-3,5-difluorophenyl} ethyl)-L-alaninate or a salt, hydrate or solvate thereof. The present invention also provides a pharmaceutical composition comprising the compound together with one or more pharmaceutically acceptable carriers and/or excipients. The compound and composition are useful for inhibiting the activity of a p38 MAP kinase enzyme. As such they may be used in the treatment of a autoimmune or inflammatory disease, or a cell proliferative disease. In addition, the invention provides an acid produced by hydrolysis of the ester group of the compound of the invention. The acid is N-[2-{ 4-[6-amino-5-(2,4-difluorobenzoyl)-2- oxopyridin-1(2H)-yl]-3,5-difluorophenyl} ethyl)-L-alanine.
