BERND BUETTELMANN,ROLAND JAKOB-ROETNE,HENNER KNUST,ANDREW THOMAS
申请号：
BRPI0814718
公开号：
BRPI0814718A2
申请日:
2008.06.12
申请国别(地区):
BR
年份:
2015
代理人:
摘要：
The present invention is concerned isoxazole-imidazole derivatives having affinity and selectivity for GABA A &alpha；5 receptor binding site, their manufacture, pharmaceutical compositions containing them and their use for enhancing cognition or for the treatment of cognitive disorders like Alzheimer's disease. In particular, the present invention is concerned with aryl-isoxazol-4-yl-imidazole derivatives of formula I wherein R1, R2 and R3 are as described in the specification.
