James D. McChesney;Igor Nikoulin;Steve J. Bannister;Douglas L. Rodenburg
发明人:
James D. McChesney,Igor Nikoulin,Steve J. Bannister,Douglas L. Rodenburg
申请号：
US15243659
公开号：
US20170042815A1
申请日:
2016.08.22
申请国别(地区):
US
年份:
2017
代理人:
摘要：
In one embodiment, the present application discloses synthetic LDL nanoparticles comprising mixtures of components selected from the group consisting of phospholipids, triglycerides, cholesterol ester and free cholesterol； optionally further comprising an agent selected from the group consisting of natural antioxidants, ubiquinol and vitamin E, and methods for preparing the synthetic nanoparticles. The disclosed synthetic LDL nanoparticles are capable of selectively delivering lipophilic drugs and prodrugs to cellular targets expressing LDL receptors after intra venous injection.
