Buffer formulations for enhanced antibody stability

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专利权人:

Outlook Therapeutics; Inc.

发明人:

Cini, John,Nagi, Athena,Taddei, Maria

申请号：

AU2014337263

公开号：

AU2014337263B2

申请日:

2014.10.16

申请国别(地区):

AU

年份:

2019

代理人:

摘要：

The invention provides buffered formulations of adalimumab. The formulations comprise a buffer comprising an acetate salt, mannitol, glacial acetic acid, sodium chloride, and polysorbate 80. The formulations have an acidic pH, and enhance the thermal, conformational and colloidal stability of antibodies, including the adalimumab antibody.

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