SHIN YOUNG KEE,KIM YOUNG DEUG,JUNG HUN SOON,KIM DEUK AE,HA TAE KYUNG
申请号：
IN201727044549
公开号：
IN201727044549A
申请日:
2017.12.12
申请国别(地区):
IN
年份:
2018
代理人:
摘要：
The present invention relates to a composition for cancer cell sensitization containing as an active ingredient a substance inhibiting the expression of an oncogene of a HPV virus and more specifically to a composition for radiosensitization which is used for the treatment of cancer induced by HPV infection and contains as an active ingredient oligonucleotide having any one nucleic acid sequence selected from the group consisting of sequence numbers 1 to 10. The oligonucleotide of the present invention inhibits the expressions of E6 and E7 which are HPV virus oncoproteins thereby inhibiting the proliferation of tumor cells and enhances the sensitivity of tumor cells to radiation thereby exhibiting an excellent effect as a sensitizer that can maximize the cell death effect.
