The present invention provides use of 3-(4-hydroxy-3-methoxyphenyl)propionic acid for manufacture of pharmaceutical composition for reducing fat. Also provided is a composition including 3-(4-hydroxy-3-methoxyphenyl)propionic acid for manufacture of pharmaceutical composition for reducing fat. The composition may further include 6,7,8,3',4'-pentamethoxyflavone, 3,5,7,8,3',4'-hexamethoxyflavone, or combination thereof.本發明提供一種3-(4-羥基-3-甲氧苯基)丙酸用於製備減少脂肪累積之醫藥組合物之用途。本發明亦提供一種包含3-(4-羥基-3-甲氧苯基)丙酸之組合物用於製備減少脂肪累積之醫藥組合物之用途。該組合物可進一步包含6,7,8,3’,4’-五甲氧基黃酮、3,5,7,8,3’,4’-六甲氧基黃酮、或其組合。