PURPOSE: A NF-kappaB inhibitor containing Terminalia chebula fruit extract is provided to suppress NF-kappa B activation and to prevent and treat NF-kappaB activation increase-associated diseases. CONSTITUTION: A NF-kappaB inhibitor contains Terminalia chebula fruit extract as an active ingredient. The NF-kappaB activation is suppressed using Terminalia chebula fruit extract. A transcription inhibitor which is controlled by NF-kappaB contains Terminalia chebula fruit extract as an active ingredient. A pharmaceutical composition for preventing and treating NF-kappaB activation increase-associated diseases contains Terminalia chebula fruit extract as an active ingredient.본 발명은 가자 추출물을 활성 성분으로 포함하는 NF-κB 억제제 및 가자 추출물을 이용하여 NF-κB의 활성을 억제하는 방법에 관한 것이다. 본 발명에 따른 NF-κB 억제제는 NF-κB의 활성 증가와 연관된 질병, 특히 염증성 질환의 예방 및 치료에 이용될 수 있다.
