A kind of method,The radiosurgery of roentgenogram and cone-beam CT scan for image guidance for precision registration pre-processes roentgenogram (802) area-of-interest including obtaining 2-D, it obtains 2-D radioscopic images area-of-interest and handles (804) at the about moment, it registers 2-D radioscopic images and treats preceding radioscopic image with corresponding 2-D to obtain 2-D registration results probably in processing (806), and the 2-D registration results are converted into 3-D tracking results tracking area-of-interest (807).