The invention relates to inhibitors of calcium-dependent protein kinase 1 (CDPK1) and pharmaceutical preparations thereof. The invention further relates to methods of treatment of parasitic infections, such asT. gondii,T. cruzi,P. falciparum,T. brucei, orL. majorinfections, using the novel inhibitors of the invention.本發明係關於鈣依賴性蛋白激酶1 (CDPK1)之抑制劑及其醫藥製劑。本發明進一步係關於使用本發明之新穎抑制劑治療寄生蟲感染之方法,如:弓蟲(T. gondii)、克氏錐蟲(T. cruzi)、惡性瘧原蟲(P. falciparum)、布氏錐蟲(T. brucei)或碩大利什曼原蟲(L. major)感染。