method to immunize a baby, combination vaccine and kit

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专利权人:

GLAXOSMITHKLINE BIOLOGICALS S.A.

发明人:

Michael Broeker

申请号：

BR112015014250

公开号：

BR112015014250A2

申请日:

2013.12.16

申请国别(地区):

BR

年份:

2017

代理人:

摘要：

1/1 summary “method for immunizing a baby, combination vaccine, and kit” saccharide conjugate vaccines that use diphtheria toxoid or tetanus toxoid as a carrier protein may confer protection. o against lethal challenge by diphtheria toxin or tetanus toxin. thus, in addition to a protection against bacteria whose saccharides have been linked to the carrier, such conjugate vaccines can also be used to protect against diphtheria and tetanus, so the toxoid components of diphtheria and tetanus toxoid from today's complex combination vaccines may be superfluous. therefore, the antigenic complexity of these vaccines can be reduced without reducing their range of protection, and removing these superfluous components creates space in the immunogen addition vaccine to protect against other pathogens. the same effect is not observed with a crm197 carrier, but this observation makes this carrier more attractive for conjugate vaccines that are given concurrently with baby combination vaccines containing dt and tt.1 / 1 resumo “mã‰todo para imunizar um bebãš, vacina de combinaã‡ãƒo, e, kitâ€� vacinas de conjugados de sacarã­deos que usam toxã³ide da difteria ou toxã³ide tetã¢nico como uma proteã­na carreadora podem conferir proteã§ã£o contra o desafio letal por toxina da difteria ou toxina tetã¢nica. assim, alã©m de uma proteã§ã£o contra as bactã©rias cujos sacarã­deos foram ligados ao carreador, tais vacinas de conjugados podem tambã©m ser usadas para proteger contra difteria e tã©tano, entã£o os componentes de toxã³ide da difteria e toxã³ide tetã¢nico das vacinas de combinaã§ã£o complexas atuais podem ser supã©rfluos. portanto, a complexidade antigãªnica destas vacinas pode ser reduzida sem reduzir sua amplitude de proteã§ã£o, e remover esses componentes supã©rfluos cria espaã§o na vacina para adiã§ã£o de imunogenes para proteger contra outros patã³genos. o mesmo efeito nã£o ã© observado com um carreador crm197, mas esta observaã§ã£o torna este carreador mais atraente para va

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/