The present invention describes exogenous surfactant preparations and surface-active drug delivery systems that can be used for the treatment of lung surfactant dysfunction in respiratory distress syndrome (RDS) and respiratory tract infections such as tuberculosis. The surface-active drug delivery systems relate to a drug loaded exogenous pulmonary surfactant vesicle. The vesicle can be a liposome. The vesicles achieve low surface tensions on film compression in the presence of mycobacterial lipids and address the surfactant dysfunction associated with RDS and respiratory tract infections such as tuberculosis. The invention provides for pulmonary surfactant replacement and can be administered as an aerosol or intratracheal instillation for RDS and respiratory tract infections such as tuberculosis, and can include drugs.本發明描述外源表面張力素製劑以及表面活性藥物遞送系統，可用於呼吸窘迫症候群（RDS）以及例如結核病之類的呼吸道成染中的肺表面張力素功能異常。該表面活性藥物遞送系統與載入藥物的外源肺表面張力素囊泡有關。該囊泡可為脂質體。在分枝稈菌脂質的存在下，該囊泡達到膜壓縮低表面張力並解決與RDS關聯的表面張力素功能異常以及例如結核病之類的呼吸道威染。本發明提供肺的表面張力素置換並且可針對RDS與例如結核病之類的呼吸道感染以一噴霧劑或氣管內灌注而給藥，並且可包括藥物。
