Yissum Research Development Company of the Hebrew University of Jerusalem Ltd
发明人:
Benita, Shimon,Goldstein, Danny,Debotton, Nir
申请号：
AU2006293410
公开号：
AU2006293410B2
申请日:
2006.09.20
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
The present invention concerns a delivery system comprising a polymer-based nanoparticle； and a linker comprising a first portion non-covalently anchored to said nanoparticle, wherein at least part of said first portion comprises a hydrophobic/lipophilic segment embedded in said nanoparticle； and a second portion comprising a maleimide compound exposed at the outer surface of said nanoparticle. In accordance with one embodiment, the delivery system comprises one or more targeting agents, each covalently bound to said maleimide compound. In accordance with yet another embodiment, the delivery system comprises a drug. A specific example for a linker in accordance with the invention is octadecyl-4-(maleimideomethyl)cyclohexane-carboxylic amide (OMCCA).
