A single use safety syringe comprising a fluid chamber 2, a needle assembly 14 and a separate storage chamber 4 attached laterally to the fluid chamber such that after use the needle assembly is automatically withdrawn into the storage chamber preventing accidental needle pricks. The syringe may have two plungers 6 8 which are both retracted by the same slider 10. The safety plunger 8 is then held in position via a ratchet system 16. When the syringe is used, slider 10 is compressed and due to its construction only moves fluid plunger 6 down. A bar of the slider 10 engages with a retaining clip 12 (normally engaged with clip housing 28), which is released and thus releases the needle assembly 14. Due to a vacuum created by plunger 8 when it is withdrawn, a spring and/or elastic material, the needle assembly is retracted into the storage chamber. Seals 22 prevent fluid or air entering the storage chamber.