ДЗЕ ГАВЕРНИНГ КАУНСИЛ ОФ ДЗЕ ЮНИВЕРСИТИ ОФ ТОРОНТО (CA)
发明人:
ГАННИНГ Патрик Томас (CA),ХЭФТЧЕНЕРИ Сайна (CA),ПЕЙДЖ Брент Дэвид Джордж (CA),ВАЙСС Сэмьюэль (CA),ЛАЧМЭН Хема Арти (CA),ФИШЕЛ Мелисса Л. (US)
申请号：
RU2014152697
公开号：
RU2014152697A
申请日:
2013.05.24
申请国别(地区):
RU
年份:
2016
代理人:
摘要：
1. The compound of formula I: Formula 1 or a pharmaceutically acceptable salt, solvate or prodrug thereof, wherein each of m and n is independently an integer from 0 to 3； R is selected from A, A, - (A) - (A), - ( A) - (A), - (A) - (A), - (A) - (A), - (A) - (A) - (A), - (A) - (A) - (A) , - (A) - (A) - (A) and - (A) - (A) -L- (A)； It is a cycloalkyl substituted with 0-3 groups selected from halogen, hydroxyl, amino, nitro, cyano, haloalkyl, spohalogenoalkyl, alkoxy, halogenoalkoxy, spihalogenoalkoxy, salkylthio, halogenoalkylalkio, (alkaloalkylamino) ( ) -alkoxy, (C) -alk- (C) -haloalkoxy, (C) -alk- (C) -polyhaloalkoxy, (C) -alk- (C) -alkylthio, (C) -alk- (C) - haloalkylthio, (C) -alk- (C) -polyhaloalkylthio, COH, (C = O) R5, (C = O) OR5 and (C = O) NHR5； It is a cycloalkyl or heterocycloalkyl substituted with 0-3 groups selected from halogen, hydroxyl, amino, nitro, cyano, haloalkyl, spohalogenalkyl, alkoxy, haloalkoxy, spihalogenoalkoxy, alkaloalkio, alkaloalkio, alkaloalkio, alkio (C) -alkoxy, (C) -alk- (C) -haloalkoxy, (C) -alk- (C) -polyhaloalkoxy, (C) -alk- (C) -alkylthio, (C) -alk- (C ) -haloalkylthio, (C) -alk- (C) -polyhaloalkylthio, COH, (C = O) R6, (C = O) OR6 and (C = O) NHR6； It is aryl substituted with 0-3 groups selected from halogen, hydroxyl, amino, nitro, cyano, haloalkyl, spihalogenoalkyl, alkoxy, halogenoalkoxy, spohalogenoalkoxy, salkylthio, halogenoalkylthio, spohaloalkylamino, () ) -alkoxy, (C) -alk- (C) -haloalkoxy, (C) -alk- (C) -polyhaloalkoxy, (C) -alk- (C) -alkylthio, (C) -alk- (C) - haloalkylthio, (C) -alk- (C) -polyhaloalkylthio, COH, (C = O) R7, (C = O) OR7 and (C = O) NHR7； A represents aryl substituted by 1-3 groups selected from halogen, hydroxyl, amino, nitro, cyano, haloalkyl, polyhaloalkyl, alkoxy, haloalkoxy, polyhaloalkoxy, Ca1. Соединение формулы I:Формула 1или его фармацевтически приемлемая соль, сольват или пролекарство, где каждый из m и n независимо представляет собой целое число от 0 до 3；Rвыбран из A, A, -(A)-(A), -(A)-(A
