The Trustees of the University of Pennsylvania;Laura Alexandra Johnson;Novartis AG;Danielle Cook
发明人:
Laura Alexandra Johnson,Danielle Cook
申请号：
US16087047
公开号：
US20200291354A1
申请日:
2017.03.23
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present invention relates to compositions and methods for using a minibody. Minibodies described herein comprise a secretion signal, a variable heavy chain fragment, a variable light chain fragment, a constant chain fragment, and a hinge domain between the variable light chain fragment and the constant chain fragment. One aspect includes a nucleic acid encoding a minibody. Other aspects include compositions comprising a minibody and a modified T cell comprising a nucleic acid encoding a minibody. Also included are methods and pharmaceutical compositions comprising the modified T cells for adoptive therapy and treating a condition, such as cancer.
