A method is provided for regenerating spent zirconium phosphate for reuse in sorbent dialysis treatments or other re uses as a sorbent material. The method includes contacting spent zirconium phosphate with an aqueous disinfectant solution having at least one antimicrobial agent and treating the resulting disinfected zirconium phosphate with an acidic solution to provide a treated zirconium phosphate that can be re used as a sorbent material. Sorbent cartridge products containing the regenerated spent zirconium phosphate are also provided. Methods and systems for sorbent dialysis which re use the regenerated zirconium phosphate such as part of sorbent cartridges additionally are provided.
