Immunogènes d'Escherichia coli détoxifiés

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专利权人:

GlaxoSmithKline Biologicals SA

发明人:

申请号：

EP14187138.4

公开号：

EP2837386B1

申请日:

2010.07.16

申请国别(地区):

EP

年份:

2018

代理人:

摘要：

Detoxified variants of the pathogenic E . coli 'AcfD precursor' (orf3526) have been identified that raise a substantially similar immune response in a subject as the native AcfD (orf3526) protein. The detoxified variants may be further modified to have increased solubility as compared to the native AcfD (orf3526) protein

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