Bert Vogelstein,Kenneth W. Kinzler,D. Williams Parsons,Xiaosong Zhang,Jimmy Cheng-Ho Lin,Rebecca J. Leary,Philipp Angenendt,Nickolas Papadopoulos,Victor Velculescu,Giovanni Parmigiani,Rachel Karchin,S
申请号：
US16132928
公开号：
US10704108B2
申请日:
2018.09.17
申请国别(地区):
US
年份:
2020
代理人:
摘要：
We found mutations of the R132 residue of isocitrate dehydrogenase 1 (IDH1) in the majority of grade II and III astrocytomas and oligodendrogliomas as well as in gliblastomas that develop from these lower grade lesions. Those tumors without mutations in IDH1 often had mutations at the analogous R172 residue of the closely related IDH2 gene. These findings have important implications for the pathogenesis and diagnosis of malignant gliomas.
