drug-molecule conjugate, and method for inhibiting depletion of healthy tissue during t-cell therapy

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专利权人:

THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA

发明人:

Bruce L. Levine,Carl H. June,Michael D. Kalos

申请号：

BR112015000310

公开号：

BR112015000310A2

申请日:

2013.07.12

申请国别(地区):

BR

年份:

2017

代理人:

摘要：

1/1 summary “drug-molecule conjugate, and method to inhibit depletion of healthy tissue during t-cell therapy” the invention provides a method for inhibiting the depletion of healthy tissue during t cell therapy comprising administering a drug-molecule conjugate comprising a drug and a molecule to a subject receiving t cell therapy, wherein the molecule binds to the car expressed on the surface of a t cell. The invention relates to the binding of the conjugate to the car, resulting in the internalization of the conjugate within the cell and the death of the drug-mediated cell.1 / 1 resumo “conjugado droga-molã‰cula, e, mã‰todo para inibir o esgotamento do tecido saudã�vel durante a terapia com cã‰lulas t carâ€� a invenã§ã£o fornece um mã©todo para inibir o esgotamento do tecido saudã¡vel durante a terapia com cã©lula t car compreendendo administrar um conjugado droga-molã©cula compreendendo uma droga e uma molã©cula a um indivã­duo que recebe terapia consistindo em cã©lula t car, em que a molã©cula se liga ao car expresso na superfã­cie de uma cã©lula t. a invenã§ã£o se refere ã  ligaã§ã£o do conjugado ao car, resultando na internalizaã§ã£o do conjugado dentro da cã©lula e na morte da cã©lula mediada pela droga.

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中国工程科技知识中心

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