A method includes obtaining a first image of first contrast agent uptake in non tissue of interest of a patient. The first image is generated based on data from first data from a first imaging modality. The method further includes obtaining a second image of second contrast agent uptake in tissue of interest and the non tissue of interest of the patient. The second image is generated based on second data from a second different imaging modality. The method further includes generating a first image mask based on the first image and generating a first feature image based on the second image and the first image mask. The method further includes displaying at least the first feature image.