Sami Antoine Adrien JANNIN,Geoffrey BODENHAUSEN,Lyndon EMSLEY
申请号：
US15099766
公开号：
US20160306020A1
申请日:
2016.04.15
申请国别(地区):
US
年份:
2016
代理人:
摘要：
A method for the preparation of a hyperpolarized solution of molecules comprises the steps: 1) suspending or coating of a micro-particulate matrix, which is comprising or consisting of the molecules, with a glass-forming solution or suspension comprising a DNP-suitable polarizing agent at a first temperature at which the micro-particulate matrix is not dissolving； 2) lowering the temperature leading to a frozen glassy DNP sample； 3) transferring the electron spin polarization of the polarizing agent in the glassy sample in a magnetic field to abundant nuclear spins of the glass-forming solution or suspension and/or the polarizing agent as well as to abundant nuclear spins of the molecules and cross-polarization from the abundant nuclear spins in the molecules to one different nuclear spin type in the molecules； and 4) increasing the temperature and dissolving the molecules which are hyperpolarized with respect of the different nuclear spins.
