Dayong Shi,Shuju Guo,Xiao Fan,Weishen Lu,Yongchao Cui
申请号：
US13813593
公开号：
US08816129B2
申请日:
2011.07.07
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present invention relates to chemical total synthesis methods of six novel protein tyrosine phosphatase-1B (PTP1B) inhibitors and application of the inhibitors in the preparation of medicaments for treating type 2 diabetes mellitus (T2DM). The PTP1B inhibitors use one or more of the six compounds represented by the structural formulae 1, 2, 3, 4, 5 and 6, as active components. The compounds can enhance the sensitivity of an insulin receptor by inhibiting the activity of PTP1B, thereby having a favorable therapeutic effect on insulin-resistant T2DM.
