Gerard Cauwenbergh,Pamela A. Pavco,Lyn Libertine,Karen G. Bulock,James Cardia
申请号：
US15101770
公开号：
US20160304875A1
申请日:
2014.12.04
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present invention relates to RNAi constructs with improved tissue and cellular uptake characteristics and methods of use of these compounds in dermal and fibrotic applications. Aspects of the invention provide nucleic acid molecules for the prophylactic treatment of wounding to reduce scarring. Herein, it is demonstrated that a specific nucleic acid molecule, RXI-109 (targeting connective tissue growth factor (CTGF)), given prophylactically, reduces scarring during wound healing.
