A medicament composition suitable for treating heart disease for parents, contained in a sealed container, pH value between 3.5-6.5, used for treating heart disease, and manufacturing method
An aqueous Pharmaceutical composition sterile, Ready to use, suitable for parenteral administration by infusion for the treatment of Heart conditions, packed in a Sealed container, and which has a pH between 3.5 and 6.5, which comprises (a) 100 mg / ml of 0.1 m hydrochloride Ethyl - 3 - [4 - (2 - hydroxy - 3 - isopropiiamino Phenylpropionate (hydrochloride) propoxy] esmoioi)； (b) 0.01 to 0.5 m of a buffering agent； and (c) 1 to 100 mg / ml of an Osmotic Regulatory Agent selected from at least one of Sodium Chloride, dextrose, sodium bicarbonate, Calcium chloride, potassium chloride, SODIUM LACTATE Ringer's solution and Ringer's Solution iactada. A method for their Manufacture.Claim 2: the pharmaceutical Composition of claim 1, wherein the PH is between 4.5 and 5.5. Claim 3: the pharmaceutical composition according to claim 1 or 2, wherein the Buffering Agent comprises at least one characterized glutamate, acetate, Citrate, tartrate, benzoate, lactate, gluconate, phosphate and Glycine.Claim 6: the pharmaceutical composition according to claim 1, characterized in that it is free of propylene glycol and ethanol.Una composición farmacéutica acuosa estéril, lista para su uso, adecuada para la administración parenteral mediante infusión para el tratamiento de condiciones cardiacas, envasada en un recipiente sellado, y que posee un pH entre 3,5 y 6,5, que comprende: a) 0,1 a 100 mg/ml de clorhidrato de metil-3-[4-(2-hidroxi-3-isopropiIamino)propoxi]fenilpropionato (clorhidrato de esmoIoI)； b) 0,01 a 0,5 M de un agente amortiguador； y c) 1 a 100 mg/ml de un agente de regulación osmótica seleccionado de al menos uno de cloruro de sodio, dextrosa, bicarbonato de sodio, cloruro de calcio, cloruro de potasio, lactato de sodio, solución de Ringer y solución Iactada de Ringer. Un método para su fabricación. Reivindicación 2: La composición farmacéutica de la reivindicación 1, caracterizada porque el pH se encuentra entre 4,5 y 5,5. Reivindicación 3: La composición farmacéutica
