JOHNS HOPKINS UNIVERSITY;UVIC INDUSTRY PARTNERSHIPS INC.
发明人:
BUCKLEY, JAMES, THOMAS,DENMEADE, SAMUEL, R.,ISAACS, JOHN, T.
申请号：
DK02768702
公开号：
DK1567641T3
申请日:
2002.08.23
申请国别(地区):
DK
年份:
2012
代理人:
摘要：
Disclosed herein are modified proaerolysin (PA) peptide. In some examples, the proteins include a prostate-specific protease cleavage site and can further include a prostate-tissue-specific binding domain which functionally replaces the native PA binding domain. In other examples, The proteins include a furin cleavage site and a prostate tissue-specific binding domain which functionally replaces the native PA binding domain. Methods of using such peptides to treat prostate cancer are also disclosed.
