Johan Lowinger,Bruno Lowinger,Frank DeLustro,David Cox,David A. Browdie
申请号：
US12509687
公开号：
US08252747B2
申请日:
2009.07.27
申请国别(地区):
US
年份:
2012
代理人:
摘要：
A tissue adhesive sealant includes a cross-linkable protein in a solution that when combined with a cross-linking agent solution including an aldehyde and amino acid containing species reactive with the aldehyde cross-links to form a seal. The sealant is well suited for bonding tissue alone or in combination with a patch. The ratio between the aldehyde and the amino acid containing species is between 20:1 and 1:1 on an aldehyde moiety:amino acid or peptide subunit molar basis. Particularly strong seals are formed when the protein and cross-linking agent are present in a molar ratio of between 15:1 and 1:1.
