The present invention relates to infant formula milk powder capable of preventing and alleviating infant iron deficiency anemia and a preparation method thereof. The formula milk powder comprises contents such as vegetable oil, fresh milk, whey powder, lactose powder, whey protein powder, oligosaccharides, complex vitamins, and complex minerals. The appropriate mass ratio of lactoferrin to vitamin C or an iron source (as iron) to lactoferrin and vitamin C, and the formula milk powder of the present invention is obtained by performing mixing, homogenizing, cooling, concentration and spray-drying, packaging or directly using a step-by-step mixing method. The formula milk powder comprises an appropriate amount of vitamin C and lactoferrin, and is further provided with an appropriate quantity of iron source, and the three are combined according to an appropriate proportion, so that the three substances have a synergistic effect, and the absorption and utilization rate of iron is increased dramatically, thereby not only achieving the desirable iron supplementation effect but also preventing and alleviating the infant iron deficiency anemia phenomenon.
