A medical device localization assembly includes an exterior frame, at least one lateral bar, a plurality of locating members and a targeting guide. The exterior frame includes a distal face configured to compress against tissue. The at least one lateral bar extends within the exterior frame and at least one open recess is formed between the lateral bar and the exterior frame. The plurality of locating members are positioned along an inner side of the exterior frame and the at least one lateral bar. The plurality of locating members extend into the at least one open recess and the at least one open recess is configured to removably receive the targeting guide at the proximal face. The plurality of locating members are sized and shaped to removably hold the guide cube such that the plurality of locating members are configured to correspond to the shape of the targeting guide.
