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HEPATITIS B VIRUS SURFACE ANTIGEN EPITOP AND ITS APPLICATION
专利权人:
ГРИН КРОСС КОРПОРЕЙШН (KR)
发明人:
КИМ Се-Хо (KR),ХОНГ Кванг-Вон (KR),ШИН Йонг-Вон (KR),ЧАНГ Ки Хван (KR),КИМ Мин-Соо (KR),ИМ Дзунг-Ае (KR)
申请号:
RU2014102957/10
公开号:
RU2014102957A
申请日:
2011.07.25
申请国别(地区):
RU
年份:
2015
代理人:
摘要:
1. Epitope specific for hepatitis B virus (HBV), containing RFLWE (SEQ ID NO: 4) and KFLWE (SEQ ID NO: 5) .2. The epitope according to claim 1, which contains the sequence FARFLWEWASVRFSW (SEQ ID NO: 6) or FGKFLWEWASARFSW (SEQ ID NO: 7). A composition comprising a combination of an epitope specific for HBV according to claim 1 or 2 with a carrier. The composition according to claim 3, in which the carrier is represented by at least one of the following substances: a peptide, serum albumin, immunoglobulin, hemocyanin and polysaccharides. The polynucleotide encoding an epitope specific for HBV according to claim 1 or 2.6. A recombinant vector comprising a polynucleotide according to claim 5.7. The recombinant vector according to claim 6, further comprising a sequence encoding a promoter or signal protein, provides the expression of an epitope specific for HBV on the surface of a microorganism or virus cell, or mammalian cells. A recombinant microorganism transformed with a recombinant vector according to claim 6 or 7.9. Recombinant virus transformed with the recombinant vector according to claim 6 or 7.10. A recombinant mammalian cell transformed with a recombinant vector according to claim 6 or 7.11. The recombinant microorganism of claim 8, wherein the transformed recombinant microorganism is represented by recombinant E. coli or recombinant yeast. The recombinant virus according to claim 9, wherein the virus is represented by recombinant bacteriophages. A method for producing an epitope specific for HBV defined by any of SEQ ID NO: 4-7, comprising: a recombinant vector according to any one of claims 6-7, culturing a recombinant microorganism according to claim 8 or 11 or a virus according to any one of claims 9 or 12 or recombinant mammalian cells according to claim 10.14. Epi vaccine composition1. Эпитоп, специфичный для вируса гепатита В (ВГВ), содержащий RFLWE (SEQ ID NO:4) и KFLWE (SEQ ID NO:5).2. Эпитоп по п.1, который содержит последовательность FARFLWEWASVRF
来源网站:
中国工程科技知识中心
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