MACDONALD LYNN,STEVENS SEAN,GURER CAGAN,MURPHY ANDREW J,HOSIAWA KAROLINA A
申请号:
IN104/CHENP/2013
公开号:
IN2013CN00104A
申请日:
2013.01.04
申请国别(地区):
IN
年份:
2015
代理人:
摘要:
A mouse comprising in its germline, at an endogenous mouse light chain locus, a human X light chain variable region sequence, wherein the human lambda variable region sequence is expressed in a light chain that comprises a mouse immunoglobulin constant region gene sequence.The mouse of claim 1, wherein the endogenous mouse light chain locus is a a locus.